This page of IGN’s Mass Effect wiki guide is all about the Virmire level, including how to get through all combat encounters, where to find every source of loot, and pick the right dialogue choices for your playthrough.
After concluding two of the leads on Saren, Shepard is contacted by the Council on news of an STG team who sent an urgent message from Virmire while gathering intel on Saren there. It’ll be a good idea to investigate the area and see what they’ve found, and if you can help.
Virmire Choices and Consequences
If you don’t want a full walkthrough but do want to know about pivotal choices you’ll have to make, here are the big ones.
Virmire: Wrex and the Genophage
Early into the Mission on Virmire, you’ll learn that Saren has found a cure for the Genophage in this lab, and Wrex is furious that it’ll be destroyed. You’ll have to confront him at the beach to find a resolution.
To convince Wrex to stand down, you’ll need to have 8 Charm points or have completed the “Wrex: Family Armor” Assignment in order to open up the requisite options to save him. Otherwise, you can shoot him yourself, order Ashley to shoot him if you told her to “Stay Alert” earlier, or can’t find a resolution that will result in Ashley killing him herself.
Virmire: Kaidan and Ashley
Towards the end of Virmire, you’ll be forced to choose to rescue either Kaidan or Ashley, who will be at the bomb site or the AA tower (who is where depends on who you assigned to Kirrahe’s team before the assault).
Saren Conversation on Virmire
At the end of the Virmire Mission, you’ll get into an extended conversation with Saren over his allyship with Sovereign. Towards the end you’ll have an Investigate option on the left side: this marks when the important final choice with Saren will appear.
If you pick “It’s already happened!” or “You are indoctrinated”, you’ll open up Persuasion options that will have an effect later in the game.